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TD52 dihydrochloride

CAT: 0931-T35528L-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T35528L-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Akt, Apoptosis, Phosphatase, Others
Related Pathways
Cytoskeletal Signaling, Metabolism, PI3K/Akt/mTOR signaling, Others, Apoptosis
Purity
0.9846
Bioactivity
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A) . It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti-cancer activity while displaying less inhibition of p-EGFR.
Smiles
C#CC1=CC=CC(NC2=NC3=C(N=C2NC4=CC(C#C)=CC=C4)C=CC=C3)=C1.Cl.Cl
Molecular Formula
C24H18Cl2N4
Molecular Weight
433.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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