X-376

CAT: 0931-T3550-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T3550-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1365267-27-1
Target
C-Met/HGFR|||ALK
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors
Purity
0.9872
Bioactivity
X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Smiles
C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Molecular Formula
C25H25Cl2FN6O3
Molecular Weight
547.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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