X-376

• CAS Number :

  1365267-27-1

• Target :

  C-Met/HGFR|||ALK

• Related Pathways :

  Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity :

  0.9872

• Bioactivity :

  X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins, and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.

• Smiles :

  C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl

• Molecular Formula :

  C25H25Cl2FN6O3

• Molecular Weight :

  547.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C