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(E) -5- (2-Bromovinyl) uracil

CAT: 0931-T35439-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T35439-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
69304-49-0
Target
Others, DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others
Bioactivity
(E) -5- (2-Bromovinyl) uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E) -5- (2-bromovinyl) -2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.
Smiles
C(=C/Br)\C=1C(=O)NC(=O)NC1
Molecular Formula
C6H5BrN2O2
Molecular Weight
217.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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