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AC-4-130

CAT: 0931-T35429-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T35429-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1834571-82-2
Target
STAT, Apoptosis, Others
Related Pathways
JAK/STAT signaling, Others, Apoptosis, Stem Cells
Bioactivity
AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].
Smiles
CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(cc2)C(O)=O)cc(c1)C(C)(C)C
Molecular Formula
C37H36ClF5N2O5S
Molecular Weight
751.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
BA2752-5.1AC-4-130
A18314-100AC-4-130 100mg
A18314-10AC-4-130 10mg
A18314-25AC-4-130 25mg
A18314-5AC-4-130 5mg
A18314-50AC-4-130 50mg
222596STF 210-130*130-B7527 AC Signs
222834STF 212-130*130-B7541 AC Signs
sc-32321 ACAnnexin V (130) AC
222598STF 211-130*130-B7527 AC Signs

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