RO8994

CAT: 0931-T3517-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T3517-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1309684-94-3
Target
Apoptosis|||E1/E2/E3 Enzyme|||Mdm2|||MDM-2/p53|||p53
Related Pathways
Apoptosis|||Ubiquitination
Purity
0.9944
Bioactivity
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays) .
Smiles
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O
Molecular Formula
C31H31Cl2FN4O4
Molecular Weight
613.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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A20865-50RO8994 50mg
A20865-100RO8994 100mg
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