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S49076 HCl

CAT: 0931-T3512-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T3512-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1265966-31-1
Target
C-Met/HGFR, FGFR, TAM Receptor
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in vivo. In cell models, S49076 HCl inhibited the proliferation of MET- and FGFR2-dependent gastric cancer cells blocked MET-driven migration of lung carcinoma cells, and inhibited colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL. In tumor xenograft models, a good pharmacokinetic/pharmacodynamic relationship for MET and FGFR2 inhibition following oral administration of S49076 HCl was established and correlated well with impact on tumor growth.
Smiles
Cl.O=C1CSC(=O)N1Cc1ccc2NC(=O)\C(=C/c3cc(CN4CCOCC4)c[nH]3)c2c1
Molecular Formula
C22H18ClN3O5
Molecular Weight
439.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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