PF-04856264

• CAS Number :

  1235397-05-3

• Target :

  Sodium Channel

• Related Pathways :

  Membrane transporter/Ion channel

• Purity :

  0.9743

• Bioactivity :

  PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.

• Smiles :

  N#CC1=CC(=CC=C1OC=2C=CC=CC2C3=CC=NN3C)S(=O)(=O)NC4=NC=CS4

• Molecular Formula :

  C20H15N5O3S2

• Molecular Weight :

  437.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C