NLCQ-1 HCl

CAT: 0931-T33699-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T33699-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

221292-08-6

Target

Others

Related Pathways

Others

Bioactivity

NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypoxic cytotoxin ranged between 10 and 136 microM x h, for the cell lines tested, at 30 microM input concentration. NLCQ-1 was a very potent and efficient radiosensitizer of hypoxic V79 cells, providing SER values of 2.27-2.56 at 20-80 microM concentration (measured at 10% survival level) . Preclinical results suggest a possible use of NLCQ-1 as adjuvants to radiotherapy.

Smiles

Cl.O=N(=O)C1=NC=CN1CCCNC=2C=CN=C3C=C(Cl)C=CC32

Molecular Formula

C15H15Cl2N5O2

Molecular Weight

368.22

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-126452	NLCQ-1
MBS5783240	NLCQ-1 HCl
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane
OR312388	1-Phenylbicyclo[1.1.1]pentane
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NLCQ-1 HCl

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