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Ombuoside

CAT: 0804-HY-N3138Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3138Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candida albicans[1][2][3][4][5]
CAS Number
20188-85-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Caspase; ERK; Fungal; JNK; Reactive Oxygen Species (ROS) ; SOD
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ombuoside.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(O[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO[C@H](O[C@H]3C)[C@@H]([C@@H]([C@H]3O)O)O)=C(C(C=C4)=CC(O)=C4OC)OC5=CC(OC)=CC(O)=C15
Molecular Formula
C29H34O16
Molecular Weight
638.57
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu X, et al. New application of ombuoside in protecting auditory cells from cisplatin-induced ototoxicity via the apoptosis pathway. Heliyon. 2024 Oct 9;10 (20) :e39166. |[2]Davaasambuu U, et al.Ombuoside from Gynostemma pentaphyllum Protects PC12 Cells from L-DOPA-Induced Neurotoxicity. Planta Med. 2018 Sep;84 (14) :1007-1012. |[3]Uchralsaikhan Davaasambuu1, et al. Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells. Natural Product Sciences 2018;24 (2) :99-102.|[4]Amaro-Luis JM, et al. Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora. Ann Pharm Fr. 1997;55 (6) :262-8. |[5]Abreu PM, et al. Antioxidant compounds from Ebenus pinnata. Fitoterapia. 2007 Jan;78 (1) :32-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; ERK1; ERK2; JNK1

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