PF-04418948

• Target:

  Prostaglandin Receptor

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation

• Purity:

  0.9945

• Bioactivity:

  PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors) . Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 ?M. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM) .

• Smiles:

  COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1

• Molecular Formula:

  C23H20FNO5

• Molecular Weight:

  409.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1078166-57-0