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PD173955

CAT: 0931-T3063-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T3063-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
260415-63-2
Target
Apoptosis, Src, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Cytoskeletal Signaling, Apoptosis
Purity
0.9928
Bioactivity
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC.
Smiles
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1
Molecular Formula
C21H16Cl2N4OS
Molecular Weight
443.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

PD173955

PD173955 is a dichlorobenzene, an aryl sulfide, a pyridopyrimidine and a methyl sulfide. It has a role as a tyrosine kinase inhibitor.

CAS Number260415-63-2
PubChem CID447077
IUPAC Name6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC21H16Cl2N4OS
Molecular Weight443.3
XLogP5.4
Topological Polar Surface Area83.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity626
SMILES
CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
InChI
InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
InChIKey
VAARYSWULJUGST-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PD173955
CAS: 260415-63-2
CID: 447077
Formula: C21H16Cl2N4OS
MW: 443.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight443.3
XLogP35.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass442.0421877
Monoisotopic Mass442.0421877
Topological Polar Surface Area83.4 Ų
Heavy Atom Count29
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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