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Hederacolchiside A1

CAT: 0931-T2P2806-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T2P2806-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
106577-39-3
Target
MEK|||ERK|||Parasite|||mTOR|||Akt|||Apoptosis|||PI3K
Related Pathways
PI3K/Akt/mTOR signaling|||Cytoskeletal Signaling|||MAPK|||Apoptosis|||Microbiology/Virology
Purity
0.9992
Bioactivity
Hederacolchiside A1 (Raddeanoside R13) shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.
Smiles
[H][C@@]1(O[C@H]2CO[C@@]([H])(O[C@H]3CC[C@@]4(C)[C@@]([H])(CC[C@]5(C)[C@]4([H])CC=C4[C@]6([H])CC(C)(C)CC[C@@]6(CC[C@@]54C)C(O)=O)C3(C)C)[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Molecular Formula
C47H76O16
Molecular Weight
897.1
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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