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AC708

CAT: 0931-T29542-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T29542-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Others
Related Pathways
Others
Bioactivity
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM) . It also inhibited the activity of growth factor-dependent cells cultured in CSF-1 (IC50 = 38 nM) or IL-34 (IC50 = 40 nM) and inhibited the differentiation and survival of primary human osteoclasts mediated by CSF-1 (IC50 = 15nM) . AC708 showed significant specificity in kinase selectivity tests against CSF1R and the closely related PDGFR family of receptors PDGFRα and β, FLT3 and KIT.
Smiles
NA
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5779176AC708

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