ZLD1039

CAT: 0931-T29231-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T29231-01Size:50 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1826865-46-6

Target

Histone Methyltransferase

Related Pathways

Chromatin/Epigenetic

Purity

0.9982

Bioactivity

ZLD1039 is a potent, orally bioavailable EZH2 (Enhancer of Zeste Homolog 2) inhibitor with high selectivity. It demonstrates strong, concentration-dependent inhibition of both wild-type and mutant (Y641F and A677G) PRC2 (Polycomb Repressive Complex 2) enzymatic activities, exhibiting IC50 values of 5.6, 15, and 4.0 nM, respectively. Additionally, ZLD1039 effectively suppresses breast tumor growth and metastasis.

Smiles

CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1

Molecular Formula

C36H48N6O3

Molecular Weight

612.8

Shipping Conditions

Ice Packs

Storage Temperature

-20°C