Upacicalcet

• Target :

  Calcium Channel|||CaSR

• Related Pathways :

  GPCR/G Protein|||Metabolism|||Membrane transporter/Ion channel

• Purity :

  0.9988

• Bioactivity :

  Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-sensitive receptors, thereby lowering blood levels of PTH.Upacicalcet is an orthosteric modulator of calcium-sensitive receptors and prevents adenine-induced secondary vascular calcification and bone disease in a rat model of adenine-induced secondary hyperparathyroidism.

• Smiles :

  N(C(NC[C@@H](C(O)=O)N)=O)C1=CC(S(=O)(=O)O)=CC(Cl)=C1C

• Molecular Formula :

  C11H14ClN3O6S

• Molecular Weight :

  351.76

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1333218-50-0