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S39625

CAT: 0931-T28648-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T28648-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
536711-20-3
Target
Others, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Others
Bioactivity
S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate.
Smiles
O=C1N2CC=3C(C2=CC4=C1CC(=O)C4(CC)O)=NC=5C(C3C6CCC6)=CC7=C(C5)OCO7
Molecular Formula
C25H22N2O5
Molecular Weight
430.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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GTR19197179-01S39625

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