RX-37

• Target:

  Others|||Epigenetic Reader Domain

• Related Pathways:

  Others|||Chromatin/Epigenetic

• Bioactivity:

  RX-37 is a potent BET inhibitor with Ki values of 3.2-24.7 nM for BRD2, BRD3 and BRD4. RX-37 demonstrates high selectivity over other non-BET bromodomain-containing proteins. RX-37 potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged mixed lineage leukemia 1 gene.

• Smiles:

  CC1=C(C2=C3C=4C(NC3=CC=N2)=CC(=C(OC)C4)C=5C(C)=NOC5C)C(=NN1)C6CC6

• Molecular Formula:

  C24H23N5O2

• Molecular Weight:

  413.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1627715-60-9