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Bicuculline

CAT: 0931-T2850-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T2850-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
485-49-4
Target
GABA Receptor
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Purity
0.9999
Bioactivity
Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM) . It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP) . Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.
Smiles
[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
Molecular Formula
C20H17NO6
Molecular Weight
367.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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