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Pradefovir

CAT: 0931-T28449-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T28449-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
625095-60-5
Target
HBV, Cytochromes P450
Related Pathways
Metabolism, Microbiology/Virology
Purity
0.975
Bioactivity
Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9- (2-phosphonylmethoxyethyl) adenine) in human liver microsomes with a K (m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.
Smiles
C(COCP1(=O)O[C@@H](CCO1)C2=CC(Cl)=CC=C2)N3C=4C(N=C3)=C(N)N=CN4
Molecular Formula
C17H19ClN5O4P
Molecular Weight
423.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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