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Isorhamnetin

CAT: 0931-T2836-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2836-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
480-19-3
Target
Endogenous Metabolite, PI3K, MEK
Related Pathways
Metabolism, PI3K/Akt/mTOR signaling, MAPK
Purity
>99.99%
Bioactivity
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.
Smiles
COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Molecular Formula
C16H12O7
Molecular Weight
316.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
N1358-20Isorhamnetin

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