Isorhamnetin

• Target:

  Endogenous Metabolite|||PI3K|||MEK

• Related Pathways:

  Metabolism|||PI3K/Akt/mTOR signaling|||MAPK

• Purity:

  >99.99%

• Bioactivity:

  Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to it's in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.

• Smiles:

  COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O

• Molecular Formula:

  C16H12O7

• Molecular Weight:

  316.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  480-19-3