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NT113

CAT: 0931-T28215-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T28215-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1398833-56-1
Target
Others
Related Pathways
Others
Bioactivity
NT113 is a pan-ERBB inhibitor with high brain penetrance. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 inhibits the growth of glioblastoma xenografts with EGFR amplification. NT113 has inhibitory activity, both in vivo and in vitro, on ERBB family member phosphorylation, as well as on the phosphorylation of downstream signaling mediator Akt.
Smiles
C(#CC=1C(NC(/C=C/CN(C)C)=O)=CC2=C(C1)N=CN=C2NC3=CC(Cl)=C(F)C=C3)[C@@H]4[C@@]5([C@]4(COC5)[H])[H]
Molecular Formula
C27H25ClFN5O2
Molecular Weight
505.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5777908NT113

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