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Manzamine A

CAT: 0931-T27977Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T27977Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
104196-68-1
Target
Others, Parasite, HSV, Autophagy, GSK-3, Proton pump, CDK
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling, Microbiology/Virology, Membrane transporter/Ion channel, Others, Stem Cells, Cell Cycle/Checkpoint
Bioactivity
Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, and decreases tau hyperphosphorylation.
Smiles
[H][C@]12C[C@]34C[N@@]5CC[C@@]3([H])C(=C[C@@](O)(CC\C=C/CCCC5)[C@]4([H])N1CCCCC=C2)c1nccc2c3ccccc3[nH]c12 |w:29.32,c:11,17|
Molecular Formula
C36H44N4O
Molecular Weight
548.775
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS5777680Manzamine A
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MBS5802672Manzamine A hydrochloride
RM-M204001-01Manzamine A (Keramamine A)
TBI2675-1MGManzamine A, Vacuolar ATPases; Autophagy inhibitor

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