K-14585

CAT: 0931-T27708Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T27708Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
880546-17-8
Target
P38 MAPK|||NF-?B|||Protease-activated Receptor|||Others
Related Pathways
MAPK|||Others|||NF-?B|||GPCR/G Protein
Bioactivity
K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR (2) -mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8.
Smiles
C(C=1C=2C(N(CC3=C(Cl)C=CC=C3Cl)C1)=CC=C(NC(NCC(N[C@H](C(N[C@H](C(NC(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)=O)C2)N7CCCC7
Molecular Formula
C51H56Cl2N8O4
Molecular Weight
915.95
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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