CBS-3595

• Target:

  PDE|||p38 MAPK|||Others

• Related Pathways:

  MAPK|||Metabolism|||Others

• Bioactivity:

  CBS-3595 is a potent and dual Inhibitor of p38? MAPK/PDE-4 with a superior profile regarding its anti-inflammatory effects. CBS-3595 features moderate inhibition of p38? MAPK and PDE-4 in the higher nanomolar range in combination with excellent kinetic properties and low plasma protein binding contributing to the outstanding results of the efficacy experiments performed in animal models and humans. The inhibition of TNF? release was achieved at dose levels and systemic concentrations that were well below levels related to toxicity.

• Smiles:

  CN1C(=C(N=C1S(C)=O)C2=CC=C(F)C=C2)C=3C=C(NC(C)=O)N=CC3

• Molecular Formula:

  C18H17FN4O2S

• Molecular Weight:

  372.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  908380-97-2