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Cavosonstat

CAT: 0931-T26955-03Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T26955-03Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1371587-51-7
Target
GSNOR, CFTR
Related Pathways
Membrane transporter/Ion channel, Metabolism
Purity
>99.99%
Bioactivity
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization. As a CFTR stabilizer, Cavosonstat can be used to study cystic fibrosis.
Smiles
OC(=O)c1ccc(c(Cl)c1)-c1ccc2cc(O)ccc2n1
Molecular Formula
C16H10ClNO3
Molecular Weight
299.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Cavosonstat

Cavosonstat is under investigation in clinical trial NCT02589236 (Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation).

CAS Number1371587-51-7
PubChem CID56960912
IUPAC Name3-chloro-4-(6-hydroxyquinolin-2-yl)benzoic acid
Molecular FormulaC16H10ClNO3
Molecular Weight299.71
XLogP3.7
Topological Polar Surface Area70.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity392
SMILES
C1=CC(=C(C=C1C(=O)O)Cl)C2=NC3=C(C=C2)C=C(C=C3)O
InChI
InChI=1S/C16H10ClNO3/c17-13-8-10(16(20)21)1-4-12(13)15-5-2-9-7-11(19)3-6-14(9)18-15/h1-8,19H,(H,20,21)
InChIKey
BXSZILNGNMDGSL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cavosonstat
CAS: 1371587-51-7
CID: 56960912
Formula: C16H10ClNO3
MW: 299.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight299.71
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass299.0349209
Monoisotopic Mass299.0349209
Topological Polar Surface Area70.4 Ų
Heavy Atom Count21
Formal Charge0
Complexity392
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA6621-50Cavosonstat

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