C188

• Target :

  Others|||Apoptosis|||STAT

• Related Pathways :

  Apoptosis|||Others|||Stem Cells|||JAK/STAT signaling

• Bioactivity :

  C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-?-stimulated HepG2 cellular STAT1 phosphorylation.

• Smiles :

  OC(=O)CSc1cc(NS(=O)(=O)c2ccc(cc2)C(O)=O)c2ccccc2c1O

• Molecular Formula :

  C19H15NO7S2

• Molecular Weight :

  433.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  823828-18-8