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PIK-75

CAT: 0931-T2667-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T2667-02Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
372196-67-3
Target
PI3K, Apoptosis, DNA-PK
Related Pathways
Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Purity
>99.99%
Bioactivity
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK (IC50=2 nM), p110α (IC50=5.8 nM) and p110γ (IC50=76 nM) .
Smiles
CN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
Molecular Formula
C16H14BrN5O4S
Molecular Weight
452.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Pik-75

N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.

CAS Number372196-67-3
PubChem CID10275789
IUPAC NameN-[(E)-(6-bromoimidazo[1,2-a]pyridin-3-yl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide
Molecular FormulaC16H14BrN5O4S
Molecular Weight452.3
XLogP3.8
Topological Polar Surface Area121
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity679
SMILES
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br
InChI
InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
InChIKey
QTHCAAFKVUWAFI-DJKKODMXSA-N
Chemical Structure
2D Structure
2D structure of Pik-75
CAS: 372196-67-3
CID: 10275789
Formula: C16H14BrN5O4S
MW: 452.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight452.3
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass450.99499
Monoisotopic Mass450.99499
Topological Polar Surface Area121 Ų
Heavy Atom Count27
Formal Charge0
Complexity679
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A2080-50PIK-75
MBS132430-01PIK 75
sc-296089PIK-75, hydrochloride
GTR19174027-01PIK-75 hydrochloride
S1205-01PIK-75 HCl

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