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A 83586C

CAT: 0931-T26456-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T26456-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
116364-81-9
Target
Others, Antibacterial, Antibiotic
Related Pathways
Others, Microbiology/Virology
Bioactivity
A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating osteopontin (Opn) expression. A-83586C also inhibits E2F-mediated transcription by downregulating E2F1 expression and inducing dephosphorylation of the oncogenic hyperphosphorylated retinoblastoma protein (pRb) .
Smiles
[C@@](C(N[C@H]1[C@H](C(C)C)OC(=O)[C@@]([C@H](C)O)(NC(=O)[C@]2(N(C(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(O)C(=O)[C@@]3(N(C1=O)NCCC3)[H])NCCC2)[H])[H])=O)(CC)(O)[C@]4(O)O[C@H](\C(=C\[C@@H](C(/C(=C/C)/C)=O)C)\C)[C@@H](C)CC4
Molecular Formula
C47H76N8O14
Molecular Weight
977.15
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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