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LY2811376

CAT: 0931-T2639-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2639-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1194044-20-6
Target
BACE, Beta-Secretase, Beta Amyloid
Related Pathways
Neuroscience
Purity
0.9901
Bioactivity
LY2811376, an orally available non-peptidic β-secretase (BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM) . It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
Smiles
C[C@]1(CCSC(N)=N1)c1cc(c(F)cc1F)-c1cncnc1
Molecular Formula
C15H14F2N4S
Molecular Weight
320.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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