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SAK3

CAT: 0931-T26174-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T26174-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1256269-87-0
Target
Calcium Channel, AChR
Related Pathways
Membrane transporter/Ion channel, Metabolism, Neuroscience
Purity
0.9955
Bioactivity
SAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective against scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells.SAK3 is used for the study of memory deficits and Alzheimer's disease. SAK3 can be used to study memory deficits and Alzheimer's disease.
Smiles
O=C(OCC)C=1C(=O)CC2(C(=O)N=C3C(=CC=CN32)C)C1N4CCCCC4
Molecular Formula
C20H23N3O4
Molecular Weight
369.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
CAS Number1256269-87-0
PubChem CID71655974
IUPAC Nameethyl 8'-methyl-2',5-dioxo-2-piperidin-1-ylspiro[cyclopentene-3,3'-imidazo[1,2-a]pyridine]-1-carboxylate
Molecular FormulaC20H23N3O4
Molecular Weight369.4
XLogP1.4
Topological Polar Surface Area79.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity845
SMILES
CCOC(=O)C1=C(C2(CC1=O)C(=O)N=C3N2C=CC=C3C)N4CCCCC4
InChI
InChI=1S/C20H23N3O4/c1-3-27-18(25)15-14(24)12-20(16(15)22-9-5-4-6-10-22)19(26)21-17-13(2)8-7-11-23(17)20/h7-8,11H,3-6,9-10,12H2,1-2H3
InChIKey
WZHBYTVHUFURPY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
CAS: 1256269-87-0
CID: 71655974
Formula: C20H23N3O4
MW: 369.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.4
XLogP31.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass369.16885622
Monoisotopic Mass369.16885622
Topological Polar Surface Area79.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity845
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5775904SAK3

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