GSK2606414

• Target :

  PERK|||Autophagy|||Apoptosis

• Related Pathways :

  Apoptosis|||Autophagy

• Purity :

  >99.99%

• Bioactivity :

  GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase (PERK) inhibitor with IC50 of 0.4 nM. GSK2606414 inhibits PERK activation in cells and suppresses the growth of human tumor xenografts in mice.

• Smiles :

  NC1=C2C(=CN(C)C2=NC=N1)C=3C=C4C(=CC3)N(C(CC5=CC(C(F)(F)F)=CC=C5)=O)CC4

• Molecular Formula :

  C24H20F3N5O

• Molecular Weight :

  451.44

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1337531-36-8