Products for Research Use Only
RegisterLogin

Aleplasinin

CAT: 0804-HY-14759-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14759-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC50=655 nM) . Aleplastinin activates the tissue type plasminogen activator (tPA) /fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease[1][2].
CAS Number
481629-87-2
Product Name Alternative
PAZ-417
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Amyloid-β; PAI-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aleplasinin.html
Purity
99.59
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C(C1=CN(CC2=CC=C(C(C)(C)C)C=C2)C3=C1C=C(C4=CC=CC(C)=C4)C=C3)=O
Molecular Formula
C28H27NO3
Molecular Weight
425.52
Precautions
H302, H315, H319
References & Citations
[1]Jacobsen JS, et al. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A. 2008 Jun 24;105 (25) :8754-9.|[2]Kellici TF, et al. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42 (6) :431-433.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
BA8054-5Aleplasinin

Popular Products