Diflorasone

CAT: 0931-T2548-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T2548-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2557-49-5

Target

Others, Glucocorticoid Receptor

Related Pathways

Others, Endocrinology/Hormones

Purity

0.9992

Bioactivity

Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE) . Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes.

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Molecular Formula

C22H28F2O5

Molecular Weight

410.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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FA17140-01	Acetyloxy diflorasone
HY-A0158R-01	Diflorasone (Standard)
TRC-D445500-100MG	Diflorasone Diacetate
A17606-50	Diflorasone 50mg
A17606-25	Diflorasone 25mg

Diflorasone

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