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GS143

CAT: 0931-T25465-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T25465-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
916232-21-8
Target
NF-κB, IκB/IKK, E1/E2/E3 Enzyme
Related Pathways
Ubiquitination, NF-κB
Purity
0.9972
Bioactivity
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. It suppresses NF-κB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.
Smiles
OC(=O)c1ccc(cc1)N1N=C(Cc2ccccc2)\C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Molecular Formula
C28H19FN2O4
Molecular Weight
466.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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