Cediranib

• Target:

  C-Kit|||PDGFR|||FLT|||VEGFR|||Autophagy

• Related Pathways:

  Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  0.9994

• Bioactivity:

  Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/?3 nM), similar activity against PDGFR? and c-Kit, selective more for VEGFR than PDGFR-? (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.

• Smiles:

  O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5

• Molecular Formula:

  C25H27FN4O3

• Molecular Weight:

  450.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  288383-20-0