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Cediranib

CAT: 0931-T2500-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T2500-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
288383-20-0
Target
C-Kit, PDGFR, FLT, VEGFR, Autophagy
Related Pathways
Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9994
Bioactivity
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
Smiles
O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5
Molecular Formula
C25H27FN4O3
Molecular Weight
450.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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