PD 151746

CAT: 0931-T2493-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T2493-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

179461-52-0

Target

Proteasome, Cysteine Protease

Related Pathways

Ubiquitination, Proteases/Proteasome

Purity

0.9863

Bioactivity

PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM) . Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].

Smiles

OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12

Molecular Formula

C11H8FNO2S

Molecular Weight

237.25

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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B4791-100	PD 151746
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PD 151746

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