PD 151746

• Target :

  Proteasome|||Cysteine Protease

• Related Pathways :

  Ubiquitination|||Proteases/Proteasome

• Purity :

  0.9863

• Bioactivity :

  PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 ?M) over m-calpain (Ki = 5.33 ± 0.77 ?M) . Its IC50 values are 0.26 ± 0.03 ?M (Ki for ?-calpain) and 5.33 ± 0.77 ?M (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].

• Smiles :

  OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12

• Molecular Formula :

  C11H8FNO2S

• Molecular Weight :

  237.25

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  179461-52-0