Hh-Ag1.5

• Target :

  Hedgehog/Smoothened

• Related Pathways :

  Stem Cells|||GPCR/G Protein

• Purity :

  0.9987

• Bioactivity :

  Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.

• Smiles :

  CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2c(F)ccc(F)c2c1Cl

• Molecular Formula :

  C28H26ClF2N3OS

• Molecular Weight :

  526.04

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  612542-14-0