Hh-Ag1.5

• Target:

  Hedgehog/Smoothened

• Related Pathways:

  Stem Cells|||GPCR/G Protein

• Purity:

  0.9987

• Bioactivity:

  Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quiescent state of non-injured hepatic stem cells and thus rescues liver failure. Hh-Ag1.5 induced differentiation of hiPSCs into skin precursor cells, spinal motor neurons and spinal sensory neurons.

• Smiles:

  CN[C@H]1CC[C@@H] (CC1) N (Cc1cccc (c1) -c1ccncc1) C (=O) c1sc2c (F) ccc (F) c2c1Cl

• Molecular Formula:

  C28H26ClF2N3OS

• Molecular Weight:

  526.04

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  612542-14-0