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KNK437

CAT: 0931-T2444-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T2444-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
218924-25-5
Target
HSP
Related Pathways
Cytoskeletal Signaling, Metabolism
Purity
0.989
Bioactivity
KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs (HSP105, HSP72, and HSP40) .
Smiles
O=CN1CCC(=Cc2ccc3OCOc3c2)C1=O
Molecular Formula
C13H11NO4
Molecular Weight
245.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Knk-437

inhibits thermotolerance acquisition and heat shock protein induction in colon carcinoma cells; structure in first source

CAS Number218924-25-5
PubChem CID46195007
IUPAC Name(3E)-3-(1,3-benzodioxol-5-ylmethylidene)-2-oxopyrrolidine-1-carbaldehyde
Molecular FormulaC13H11NO4
Molecular Weight245.23
XLogP1.5
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity392
SMILES
C\1CN(C(=O)/C1=C/C2=CC3=C(C=C2)OCO3)C=O
InChI
InChI=1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2/b10-5+
InChIKey
LZGGUFLRKIMBDQ-BJMVGYQFSA-N
Chemical Structure
2D Structure
2D structure of Knk-437
CAS: 218924-25-5
CID: 46195007
Formula: C13H11NO4
MW: 245.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight245.23
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass245.06880783
Monoisotopic Mass245.06880783
Topological Polar Surface Area55.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity392
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B5848-10KNK437
A14389-50KNK437 50mg
A14389-100KNK437 100mg
A14389-10KNK437 10mg
A14389-5KNK437 5mg
HY-100110RKNK437 (Standard)
A14389-200KNK437 200mg
A14389-25KNK437 25mg

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