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FzM1

CAT: 0931-T24076-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T24076-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1680196-54-6
Target
Wnt/beta-catenin
Related Pathways
Stem Cells, Cytoskeletal Signaling
Purity
0.9989
Bioactivity
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
Smiles
Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-116553-01FzM1
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A18760-50FzM1.8 50mg
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A18760-100FzM1.8 100mg
A18760-1FzM1.8 1mg
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A18760-5FzM1.8 5mg
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