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Bromfenac sodium hydrate

CAT: 0931-T2403-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T2403-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
120638-55-3
Target
COX
Related Pathways
Neuroscience, Immunology/Inflammation
Purity
0.9965
Bioactivity
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP) .
Smiles
O.[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c1ccc(Br)cc1
Molecular Formula
C15H12BrNO3·3/2H2O·Na
Molecular Weight
383.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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