Edoxaban

• Target:

  Factor Xa|||Thrombin

• Related Pathways:

  Metabolism|||Proteases/Proteasome

• Purity:

  0.9971

• Bioactivity:

  Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is able to be used for stroke prevention. Edoxaban is a also weak inhibitor of thrombin and factor IXa? (FIXa), with K i s of 6.00 ?M and 41.7 ?M, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban has antithrombotic properties and is potential for thromboembolic diseases treatment [1] [2] [3].

• Smiles:

  N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3

• Molecular Formula:

  C24H30ClN7O4S

• Molecular Weight:

  548.06

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  480449-70-5