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Bimiralisib

CAT: 0931-T2265-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T2265-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1225037-39-7
Target
MTOR, PI3K, S6 Kinase
Related Pathways
MAPK, PI3K/Akt/mTOR signaling
Purity
0.9988
Bioactivity
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
Smiles
Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
Molecular Formula
C17H20F3N7O2
Molecular Weight
411.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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