CFM 4

CAT: 0931-T22646-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T22646-01Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

331458-02-7

Target

APC/C, Apoptosis

Related Pathways

Cell Cycle/Checkpoint, Apoptosis

Purity

0.9882

Bioactivity

CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.CFM 4 inhibits the growth of drug-resistant human breast cancer cells.

Smiles

O=C1C2(C=3C(N1CC4=C(Cl)C=CC=C4)=CC=CC3)SC(=NN2)C5=CC=CC=C5

Molecular Formula

C22H16ClN3OS

Molecular Weight

405.9

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one

CAS Number	331458-02-7
PubChem CID	2871439
IUPAC Name	1'-[(2-chlorophenyl)methyl]-5-phenylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
Molecular Formula	C22H16ClN3OS
Molecular Weight	405.9
XLogP	5.4
Topological Polar Surface Area	70
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	28
Formal Charge	0
Complexity	637

SMILES

C1=CC=C(C=C1)C2=NNC3(S2)C4=CC=CC=C4N(C3=O)CC5=CC=CC=C5Cl

InChI

InChI=1S/C22H16ClN3OS/c23-18-12-6-4-10-16(18)14-26-19-13-7-5-11-17(19)22(21(26)27)25-24-20(28-22)15-8-2-1-3-9-15/h1-13,25H,14H2

InChIKey

PMADITKBVODKSF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 331458-02-7

CID: 2871439

Formula: C22H16ClN3OS

MW: 405.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	405.9
XLogP3	5.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	405.0702610
Monoisotopic Mass	405.0702610
Topological Polar Surface Area	70 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	637
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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CFM 4

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