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AD57 (hydrochloride)

CAT: 0931-T22552-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T22552-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2320261-72-9
Target
Others, Src, c-RET, Raf, S6 Kinase
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, PI3K/Akt/mTOR signaling, MAPK, Angiogenesis, Others
Bioactivity
AD57, as polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer blocks the receptor tyrosine kinase RET in Drosophila (IC50: 2 nM) . AD57 effectively suppresses tyrosine kinase RET, weakens the activity of numerous other kinases, and interferes with kinases downstream of RET, including Raf, Src, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism-related to cancer. Tyrosine kinase RET is probably sufficient to initiate a series of transformation events including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A, and 2B.
Smiles
Cl.CC(C)n1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)ncnc12
Molecular Formula
C22H21ClF3N7O
Molecular Weight
491.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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