JGB1741

• Target :

  Apoptosis|||Sirtuin

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis|||DNA Damage/DNA Repair

• Purity :

  0.9986

• Bioactivity :

  JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 ?M. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.

• Smiles :

  Oc1ccc2ccccc2c1\C=N\c1sc2CCCCc2c1C(=O)NCc1ccccc1

• Molecular Formula :

  C27H24N2O2S

• Molecular Weight :

  440.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1256375-38-8