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JGB1741

CAT: 0931-T22094-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T22094-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1256375-38-8
Target
Apoptosis, Sirtuin
Related Pathways
Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair
Purity
0.9986
Bioactivity
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.
Smiles
Oc1ccc2ccccc2c1\C=N\c1sc2CCCCc2c1C(=O)NCc1ccccc1
Molecular Formula
C27H24N2O2S
Molecular Weight
440.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
C3888-5JGB1741

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