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Eggmanone

CAT: 0931-T22077-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T22077-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
505068-32-6
Target
Others, PDE
Related Pathways
Others, Metabolism
Bioactivity
Eggmanone (EGM1) is a potent, selective phosphodiesterase 4 (PDE4) antagonist, exhibiting an IC50 of 72 nM specifically for PDE4D3. It shows 40- to 50-fold greater selectivity for PDE4D3 over other phosphodiesterases. The mechanism of action involves PDE4 selective antagonism by Eggmanone, which activates protein kinase A, culminating in the blockade of the Hedgehog (Hh) signaling pathway [1].
Smiles
CC(=C)Cn1c(SCC(=O)c2cccs2)nc2sc3CCCCc3c2c1=O
Molecular Formula
C20H20N2O2S3
Molecular Weight
416.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
562343Eggmanone

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