SSR 69071

CAT: 0931-MF-0051127-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0051127-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
344930-95-6
Target
Others|||Serine Protease
Related Pathways
Proteases/Proteasome|||Others
Bioactivity
SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.
Smiles
C(C)(C)C1=C2C(S(=O)(=O)N(COC=3N=C4N(C(=O)C3)C=CC=C4OCCN5CCCCC5)C2=O)=CC(OC)=C1
Molecular Formula
C27H32N4O7S
Molecular Weight
556.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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