Direct Blue 1

CAT: 0931-T2194-01Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0931-T2194-01Size:200 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2610-05-1

Target

NF-κB, Beta Amyloid, GluR

Related Pathways

Neuroscience, NF-κB

Purity

0.9779

Bioactivity

Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and operates as a potent, competitive VGLUT inhibitor, not impacting plasma membrane transporters. This compound stands out as the inaugural small molecule PrP ligand to inhibit Aβ binding.

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COc1c(ccc(c1)c1cc(c(cc1)/N=N/c1ccc2c(c1O)c(c(cc2S(=O)(=O)[O-])S(=O)(=O)[O-])N)OC)/N=N/c1ccc2c(c1O)c(c(cc2S(=O)(=O)[O-])S(=O)(=O)[O-])N.[Na+].[Na+].[Na+].[Na+]

Molecular Formula

C34H24N6Na4O16S4

Molecular Weight

992.8

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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