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CBHA

CAT: 0931-T21719-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T21719-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
174664-65-4
Target
Others, HDAC
Related Pathways
Chromatin/Epigenetic, Others, DNA Damage/DNA Repair
Bioactivity
M-Carboxycinnamic acid bishydroxamide, an effective HDAC inhibitor, shows ID50 values of 10 nM for HDAC1 and 70 nM for HDAC3 in vitro, demonstrating its potent activity. Additionally, it promotes apoptosis and inhibits tumor growth, highlighting its therapeutic potential [1][2].
Smiles
C(NO)(=O)C1=CC(C=CC(NO)=O)=CC=C1
Molecular Formula
C10H10N2O4
Molecular Weight
222.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Carboxycinnamic Acid Bishydroxamide

Carboxycinnamic Acid Bishydroxamide is a hybrid polar compound that induces terminal differentiation and/or apoptosis in various transformed cells. It is an inhibitor of histone deacetylase.

CAS Number174664-65-4
PubChem CID5353484
IUPAC NameN-hydroxy-3-[(E)-3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide
Molecular FormulaC10H10N2O4
Molecular Weight222.20
XLogP-0.1
Topological Polar Surface Area98.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity291
SMILES
C1=CC(=CC(=C1)C(=O)NO)/C=C/C(=O)NO
InChI
InChI=1S/C10H10N2O4/c13-9(11-15)5-4-7-2-1-3-8(6-7)10(14)12-16/h1-6,15-16H,(H,11,13)(H,12,14)/b5-4+
InChIKey
OYKBQNOPCSXWBL-SNAWJCMRSA-N
Chemical Structure
2D Structure
2D structure of Carboxycinnamic Acid Bishydroxamide
CAS: 174664-65-4
CID: 5353484
Formula: C10H10N2O4
MW: 222.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight222.20
XLogP3-0.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass222.06405680
Monoisotopic Mass222.06405680
Topological Polar Surface Area98.7 Ų
Heavy Atom Count16
Formal Charge0
Complexity291
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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C4327-10CBHA
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