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TMC647055 Choline Hydroxide Salt

CAT: 0931-T21537L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T21537L-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
HCV Protease
Related Pathways
Microbiology/Virology, Proteases/Proteasome
Purity
0.9944
Bioactivity
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC (50) of 82 nM) with minimal associated cell toxicity (CC (50) >20 μM) and promising pharmacokinetic profiles in rats and dogs. TMC647055 showed promising in vitro biochemical, kinetic, and virological profile that is currently undergoing clinical evaluation.
Smiles
CN(CCOCCN1C)C(C2=CC3=C(C=CC(OC)=C3)C4=C(C5CCCCC5)C(C=CC(/C(O)=N/S1(=O)=O)=C6)=C6N4C2)=O.OCC[N+](C)(C)C.[OH-]
Molecular Formula
C37H53N5O8S
Molecular Weight
727.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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